Drug interactions
Buprenorphine subdermal implant + Lurasidone
Severity: Moderate
Buprenorphine subdermal implant and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine can cause sedation and respiratory depression, and lurasidone can add to sedation and hypotension. The combination may therefore raise the risk of excessive CNS depression.
What this interaction means in plain words
Buprenorphine subdermal implant and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid partial agonism and antipsychotic sedative effects.
What to do
Monitor for sedation, respiratory depression and orthostatic hypotension, especially after dose changes. Counsel patients to avoid alcohol and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Buprenorphine subdermal implant with Lurasidone?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine can cause sedation and respiratory depression, and lurasidone can add to sedation and hypotension. The combination may therefore raise the risk of excessive CNS depression.
How serious is the interaction between Buprenorphine subdermal implant and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, respiratory depression and orthostatic hypotension, especially after dose changes. Counsel patients to avoid alcohol and other sedatives.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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