Drug interactions
Buprenorphine subdermal implant + Ribociclib
Severity: Moderate
Buprenorphine subdermal implant and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may prolong the QTc interval, so combined use can increase the risk of torsades de pointes. The implant gives sustained exposure, so the effect cannot be quickly reversed.
What this interaction means in plain words
Buprenorphine subdermal implant and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT interval prolongation.
What to do
Obtain a baseline ECG and correct electrolytes, then monitor the QTc while on ribociclib. Seek alternatives if marked prolongation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Buprenorphine subdermal implant with Ribociclib?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may prolong the QTc interval, so combined use can increase the risk of torsades de pointes. The implant gives sustained exposure, so the effect cannot be quickly reversed.
How serious is the interaction between Buprenorphine subdermal implant and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct electrolytes, then monitor the QTc while on ribociclib. Seek alternatives if marked prolongation occurs.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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