Drug interactions
Buprenorphine subdermal implant + Tacrolimus
Severity: Moderate
Buprenorphine subdermal implant and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus and buprenorphine can each prolong the QT interval, so combining them may add to arrhythmia risk. Buprenorphine from the implant is at a low, steady exposure, which limits the practical concern.
What this interaction means in plain words
Buprenorphine subdermal implant and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Check a baseline ECG and keep potassium and magnesium in the normal range. Monitor the QTc, especially if other QT-prolonging drugs are added.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Buprenorphine subdermal implant and Tacrolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Buprenorphine subdermal implant with Tacrolimus?
MediHelp rates the interaction as moderate. Buprenorphine subdermal implant and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus and buprenorphine can each prolong the QT interval, so combining them may add to arrhythmia risk. Buprenorphine from the implant is at a low, steady exposure, which limits the practical concern.
How serious is the interaction between Buprenorphine subdermal implant and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and keep potassium and magnesium in the normal range. Monitor the QTc, especially if other QT-prolonging drugs are added.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
