Drug interactions
Buprenorphine subdermal implant + Tizanidine
Severity: Major
Buprenorphine subdermal implant and Tizanidine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tizanidine can add to the sedative and respiratory depressant effects of buprenorphine. Hypotension may also occur.
What this interaction means in plain words
Buprenorphine subdermal implant and Tizanidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression from alpha-2 agonism and opioid receptor partial agonism.
What to do
Reserve for patients without alternatives and start tizanidine at a low dose. Monitor for sedation, bradycardia, hypotension and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Frequently asked questions
Can I take Buprenorphine subdermal implant with Tizanidine?
MediHelp rates the interaction as major. Buprenorphine subdermal implant and Tizanidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tizanidine can add to the sedative and respiratory depressant effects of buprenorphine. Hypotension may also occur.
How serious is the interaction between Buprenorphine subdermal implant and Tizanidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve for patients without alternatives and start tizanidine at a low dose. Monitor for sedation, bradycardia, hypotension and respiratory depression.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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