Drug interactions
Buprenorphine transdermal + Entacapone
Severity: Moderate
Buprenorphine transdermal and Entacapone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Buprenorphine can cause sedation and dizziness, and entacapone may add to somnolence and orthostatic effects. The combination can impair alertness.
What this interaction means in plain words
Buprenorphine transdermal and Entacapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects.
What to do
Monitor for sedation and orthostatic hypotension, especially after dose changes. Advise caution with driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Entacapone
- Entacapone + Isocarboxazid Contraindicated
- Entacapone + Phenelzine Contraindicated
- Entacapone + Tranylcypromine Contraindicated
- Amisulpride + Entacapone Major
- Entacapone + Metoclopramide Major
- Entacapone + Metoclopramide intranasal Major
Frequently asked questions
Can I take Buprenorphine transdermal with Entacapone?
MediHelp rates the interaction as moderate. Buprenorphine transdermal and Entacapone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Buprenorphine can cause sedation and dizziness, and entacapone may add to somnolence and orthostatic effects. The combination can impair alertness.
How serious is the interaction between Buprenorphine transdermal and Entacapone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and orthostatic hypotension, especially after dose changes. Advise caution with driving.
What other medicines interact with Entacapone?
MediHelp also lists interactions of Entacapone with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Entacapone page.
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