Drug interactions
Buprenorphine transdermal + Fluphenazine
Severity: Moderate
Buprenorphine transdermal and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluphenazine and transdermal buprenorphine both cause sedation, and each can contribute to QT prolongation. The combination may increase drowsiness, impaired alertness and respiratory depression, and may raise arrhythmia risk in susceptible patients.
What this interaction means in plain words
Buprenorphine transdermal and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and possible additive QT prolongation.
What to do
Use the lowest effective doses and monitor for sedation and slowed breathing. Obtain an ECG and correct electrolytes if other QT-prolonging risks are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Frequently asked questions
Can I take Buprenorphine transdermal with Fluphenazine?
MediHelp rates the interaction as moderate. Buprenorphine transdermal and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluphenazine and transdermal buprenorphine both cause sedation, and each can contribute to QT prolongation. The combination may increase drowsiness, impaired alertness and respiratory depression, and may raise arrhythmia risk in susceptible patients.
How serious is the interaction between Buprenorphine transdermal and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and slowed breathing. Obtain an ECG and correct electrolytes if other QT-prolonging risks are present.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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