Drug interactions
Buprenorphine transdermal + Gemifloxacin
Severity: Moderate
Buprenorphine transdermal and Gemifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal buprenorphine carries a QT-prolongation warning at higher doses. Together with gemifloxacin the risk of arrhythmia may be increased.
What this interaction means in plain words
Buprenorphine transdermal and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization.
What to do
Consider an alternative antibiotic in patients with QT risk factors. If both are used, monitor ECG and correct electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Buprenorphine transdermal with Gemifloxacin?
MediHelp rates the interaction as moderate. Buprenorphine transdermal and Gemifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Transdermal buprenorphine carries a QT-prolongation warning at higher doses. Together with gemifloxacin the risk of arrhythmia may be increased.
How serious is the interaction between Buprenorphine transdermal and Gemifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative antibiotic in patients with QT risk factors. If both are used, monitor ECG and correct electrolytes.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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