Drug interactions
Buprenorphine transdermal + Moxifloxacin
Severity: Major
Buprenorphine transdermal and Moxifloxacin: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Transdermal buprenorphine has been associated with QT prolongation, and moxifloxacin adds to it. The combination may increase the risk of torsades de pointes, particularly at higher buprenorphine doses.
What this interaction means in plain words
Buprenorphine transdermal and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Prefer a non-QT-prolonging antibiotic. If the combination is needed, monitor ECG and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Buprenorphine transdermal with Moxifloxacin?
MediHelp rates the interaction as major. Buprenorphine transdermal and Moxifloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Transdermal buprenorphine has been associated with QT prolongation, and moxifloxacin adds to it. The combination may increase the risk of torsades de pointes, particularly at higher buprenorphine doses.
How serious is the interaction between Buprenorphine transdermal and Moxifloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-QT-prolonging antibiotic. If the combination is needed, monitor ECG and electrolytes.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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