Drug interactions
Bupropion + Butalbital
Severity: Moderate
Bupropion and Butalbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital is a barbiturate that can induce hepatic enzymes and may lower bupropion levels. Efficacy may be reduced, particularly with frequent butalbital use.
What this interaction means in plain words
Bupropion and Butalbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Enzyme induction by butalbital increases bupropion metabolism.
What to do
Monitor clinical response to bupropion, especially with regular butalbital use. Adjust the dose within labeled limits if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Butalbital?
MediHelp rates the interaction as moderate. Bupropion and Butalbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital is a barbiturate that can induce hepatic enzymes and may lower bupropion levels. Efficacy may be reduced, particularly with frequent butalbital use.
How serious is the interaction between Bupropion and Butalbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to bupropion, especially with regular butalbital use. Adjust the dose within labeled limits if needed.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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