Drug interactions
Bupropion + Cannabidiol
Severity: Moderate
Bupropion and Cannabidiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol can inhibit and possibly induce CYP2B6, the main enzyme converting bupropion to hydroxybupropion, so bupropion exposure may change unpredictably. Higher exposure could increase adverse effects such as seizures, while lower exposure could reduce efficacy.
What this interaction means in plain words
Bupropion and Cannabidiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Cannabidiol belongs to Central Nervous System.
Why it happens
Cannabidiol modulates CYP2B6 activity (inhibition and possible induction), altering bupropion metabolism.
What to do
Monitor for bupropion adverse effects (insomnia, agitation, tremor, seizures) and for loss of efficacy when starting or stopping cannabidiol. Adjust the bupropion dose according to clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Tacrolimus Major
- Cannabidiol + Valproic acid Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Bupropion with Cannabidiol?
MediHelp rates the interaction as moderate. Bupropion and Cannabidiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol can inhibit and possibly induce CYP2B6, the main enzyme converting bupropion to hydroxybupropion, so bupropion exposure may change unpredictably. Higher exposure could increase adverse effects such as seizures, while lower exposure could reduce efficacy.
How serious is the interaction between Bupropion and Cannabidiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bupropion adverse effects (insomnia, agitation, tremor, seizures) and for loss of efficacy when starting or stopping cannabidiol. Adjust the bupropion dose according to clinical response.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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