Drug interactions
Bupropion + Carvedilol
Severity: Moderate
Bupropion and Carvedilol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion may raise carvedilol concentrations by inhibiting CYP2D6, which can increase beta-blocking and vasodilating effects such as hypotension and bradycardia.
What this interaction means in plain words
Bupropion and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Carvedilol belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6-mediated carvedilol metabolism by bupropion.
What to do
Monitor blood pressure and heart rate when starting or adjusting bupropion. Lower the carvedilol dose if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Carvedilol
Frequently asked questions
Can I take Bupropion with Carvedilol?
MediHelp rates the interaction as moderate. Bupropion and Carvedilol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion may raise carvedilol concentrations by inhibiting CYP2D6, which can increase beta-blocking and vasodilating effects such as hypotension and bradycardia.
How serious is the interaction between Bupropion and Carvedilol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting or adjusting bupropion. Lower the carvedilol dose if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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