Drug interactions
Bupropion + Cenobamate
Severity: Moderate
Bupropion and Cenobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate may induce CYP2B6, which could lower bupropion and hydroxybupropion concentrations and reduce antidepressant or smoking cessation effectiveness. The effect is generally gradual and of modest to moderate size.
What this interaction means in plain words
Bupropion and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Cenobamate belongs to Central Nervous System.
Why it happens
Cenobamate induces CYP2B6, increasing bupropion metabolism.
What to do
Monitor for reduced clinical response to bupropion and increase the dose within labeled limits if needed. Reassess the dose if cenobamate is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bupropion and Cenobamate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Bupropion with Cenobamate?
MediHelp rates the interaction as moderate. Bupropion and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate may induce CYP2B6, which could lower bupropion and hydroxybupropion concentrations and reduce antidepressant or smoking cessation effectiveness. The effect is generally gradual and of modest to moderate size.
How serious is the interaction between Bupropion and Cenobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced clinical response to bupropion and increase the dose within labeled limits if needed. Reassess the dose if cenobamate is stopped.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
