Drug interactions
Bupropion + Dexfenfluramine
Severity: Minor
Bupropion and Dexfenfluramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion inhibits CYP2D6, which may modestly increase dexfenfluramine exposure. Both drugs affect monoamine systems, so adverse effects such as agitation could be more likely, though dexfenfluramine is withdrawn from the market.
What this interaction means in plain words
Bupropion and Dexfenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP2D6 inhibition by bupropion may reduce dexfenfluramine metabolism.
What to do
Monitor for adverse effects such as agitation and serotonergic symptoms. Adjust the dose if these appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Dexfenfluramine?
MediHelp rates the interaction as minor. Bupropion and Dexfenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bupropion inhibits CYP2D6, which may modestly increase dexfenfluramine exposure. Both drugs affect monoamine systems, so adverse effects such as agitation could be more likely, though dexfenfluramine is withdrawn from the market.
How serious is the interaction between Bupropion and Dexfenfluramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for adverse effects such as agitation and serotonergic symptoms. Adjust the dose if these appear.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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