Drug interactions
Bupropion + Dextroamphetamine transdermal
Severity: Moderate
Bupropion and Dextroamphetamine transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion inhibits CYP2D6, which contributes to amphetamine metabolism, so amphetamine exposure may rise. Both drugs also increase noradrenergic and dopaminergic activity and lower seizure threshold, raising the risk of agitation, hypertension, seizures and serotonin toxicity.
What this interaction means in plain words
Bupropion and Dextroamphetamine transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP2D6 inhibition by bupropion increases amphetamine levels, with additive pharmacodynamic stimulant and seizure-threshold effects.
What to do
Use lower starting doses of dextroamphetamine and titrate slowly. Monitor blood pressure, heart rate, mental status and seizure activity, especially after dose increases.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Dextroamphetamine transdermal?
MediHelp rates the interaction as moderate. Bupropion and Dextroamphetamine transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion inhibits CYP2D6, which contributes to amphetamine metabolism, so amphetamine exposure may rise. Both drugs also increase noradrenergic and dopaminergic activity and lower seizure threshold, raising the risk of agitation, hypertension, seizures and serotonin toxicity.
How serious is the interaction between Bupropion and Dextroamphetamine transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use lower starting doses of dextroamphetamine and titrate slowly. Monitor blood pressure, heart rate, mental status and seizure activity, especially after dose increases.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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