Drug interactions
Bupropion + Dextroamphetamine
Severity: Moderate
Bupropion and Dextroamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are stimulants that lower seizure threshold, and bupropion may raise amphetamine exposure via CYP2D6 inhibition. Risks include seizures, anxiety, hypertension, and tachycardia.
What this interaction means in plain words
Bupropion and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion belongs to Central Nervous System; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Additive CNS stimulation and seizure-threshold lowering, with CYP2D6 inhibition by bupropion.
What to do
Use the lowest effective doses and monitor blood pressure, heart rate, and seizure activity. Avoid in patients with seizure history.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Bupropion with Dextroamphetamine?
MediHelp rates the interaction as moderate. Bupropion and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are stimulants that lower seizure threshold, and bupropion may raise amphetamine exposure via CYP2D6 inhibition. Risks include seizures, anxiety, hypertension, and tachycardia.
How serious is the interaction between Bupropion and Dextroamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor blood pressure, heart rate, and seizure activity. Avoid in patients with seizure history.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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