Drug interactions
Bupropion + Diazepam intranasal
Severity: Minor
Bupropion and Diazepam intranasal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion is not a sedative, so additive CNS depression is not expected. Abrupt benzodiazepine discontinuation while on bupropion increases seizure risk, and diazepam is itself used for seizures.
What this interaction means in plain words
Bupropion and Diazepam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
No established pharmacokinetic or pharmacodynamic mechanism for CNS depression; seizure threshold changes occur with benzodiazepine withdrawal.
What to do
No routine adjustment needed. Avoid abrupt benzodiazepine discontinuation in patients on bupropion.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Diazepam intranasal?
MediHelp rates the interaction as minor. Bupropion and Diazepam intranasal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bupropion is not a sedative, so additive CNS depression is not expected. Abrupt benzodiazepine discontinuation while on bupropion increases seizure risk, and diazepam is itself used for seizures.
How serious is the interaction between Bupropion and Diazepam intranasal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment needed. Avoid abrupt benzodiazepine discontinuation in patients on bupropion.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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