Drug interactions
Bupropion + Fexinidazole
Severity: Moderate
Bupropion and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may induce CYP2B6, the enzyme that converts bupropion to hydroxybupropion. This may reduce bupropion exposure and its antidepressant or smoking-cessation effect. The fexinidazole course is short, so effects are likely temporary.
What this interaction means in plain words
Bupropion and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Fexinidazole induces CYP2B6, increasing bupropion metabolism.
What to do
Monitor for reduced bupropion response during and shortly after fexinidazole treatment. Consider whether bupropion dosing needs adjusting if symptoms recur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Fexinidazole?
MediHelp rates the interaction as moderate. Bupropion and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may induce CYP2B6, the enzyme that converts bupropion to hydroxybupropion. This may reduce bupropion exposure and its antidepressant or smoking-cessation effect. The fexinidazole course is short, so effects are likely temporary.
How serious is the interaction between Bupropion and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced bupropion response during and shortly after fexinidazole treatment. Consider whether bupropion dosing needs adjusting if symptoms recur.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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