Drug interactions
Bupropion + Iobenguane i
Severity: Major
Bupropion and Iobenguane i: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iobenguane is taken up into cells via the norepinephrine transporter. Bupropion inhibits catecholamine reuptake and may block uptake of iobenguane into target tissue, reducing its imaging or therapeutic efficacy.
What this interaction means in plain words
Bupropion and Iobenguane i can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Bupropion inhibits norepinephrine transporter uptake, competing with iobenguane cellular uptake.
What to do
Stop bupropion for at least 5 half-lives before dosimetry or therapeutic iobenguane doses and withhold it for at least 7 days after each dose, consistent with labeling. Arrange alternative management of depression or smoking cessation in the interim.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Iobenguane i?
MediHelp rates the interaction as major. Bupropion and Iobenguane i can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iobenguane is taken up into cells via the norepinephrine transporter. Bupropion inhibits catecholamine reuptake and may block uptake of iobenguane into target tissue, reducing its imaging or therapeutic efficacy.
How serious is the interaction between Bupropion and Iobenguane i?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop bupropion for at least 5 half-lives before dosimetry or therapeutic iobenguane doses and withhold it for at least 7 days after each dose, consistent with labeling. Arrange alternative management of depression or smoking cessation in the interim.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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