Drug interactions
Bupropion + Ioflupane i
Severity: Moderate
Bupropion and Ioflupane i: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion binds the dopamine transporter and may compete with ioflupane I-123 at that site, potentially reducing striatal uptake and affecting image interpretation in DaTscan studies. This could lead to a falsely abnormal or less reliable scan.
What this interaction means in plain words
Bupropion and Ioflupane i can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competitive binding at the dopamine transporter reduces radiotracer uptake.
What to do
Consult the nuclear medicine team before imaging; consider whether bupropion can be temporarily withheld, and interpret the scan with the medication in mind if it cannot.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Ioflupane i?
MediHelp rates the interaction as moderate. Bupropion and Ioflupane i can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion binds the dopamine transporter and may compete with ioflupane I-123 at that site, potentially reducing striatal uptake and affecting image interpretation in DaTscan studies. This could lead to a falsely abnormal or less reliable scan.
How serious is the interaction between Bupropion and Ioflupane i?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consult the nuclear medicine team before imaging; consider whether bupropion can be temporarily withheld, and interpret the scan with the medication in mind if it cannot.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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