Drug interactions
Bupropion + Lumacaftor / ivacaftor
Severity: Moderate
Bupropion and Lumacaftor / ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is an enzyme inducer and may lower exposure to CYP2B6 substrates such as bupropion, whereas ivacaftor may weakly inhibit CYP2B6. The net effect is likely reduced bupropion activity, potentially causing loss of efficacy.
What this interaction means in plain words
Bupropion and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor induction of CYP2B6 and other enzymes, with possible weak inhibition by ivacaftor.
What to do
Monitor clinical response to bupropion and increase the dose if efficacy is lost, staying within the maximum labeled dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Lumacaftor / ivacaftor?
MediHelp rates the interaction as moderate. Bupropion and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is an enzyme inducer and may lower exposure to CYP2B6 substrates such as bupropion, whereas ivacaftor may weakly inhibit CYP2B6. The net effect is likely reduced bupropion activity, potentially causing loss of efficacy.
How serious is the interaction between Bupropion and Lumacaftor / ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to bupropion and increase the dose if efficacy is lost, staying within the maximum labeled dose.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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