Drug interactions
Bupropion + Methylthioninium chloride
Severity: Major
Bupropion and Methylthioninium chloride: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylene blue inhibits MAO-A and, combined with serotonergic or dopaminergic antidepressants, can cause serotonin syndrome. Bupropion also inhibits CYP2D6 and may further complicate toxicity.
What this interaction means in plain words
Bupropion and Methylthioninium chloride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bupropion belongs to Central Nervous System; Methylthioninium chloride belongs to Miscellaneous.
Why it happens
MAO-A inhibition by methylene blue combined with additive serotonergic/monoaminergic activity.
What to do
Avoid if possible; if methylene blue is urgently needed, withhold bupropion and monitor for serotonin syndrome for several days.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methylthioninium chloride
Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Methylthioninium chloride?
MediHelp rates the interaction as major. Bupropion and Methylthioninium chloride can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methylene blue inhibits MAO-A and, combined with serotonergic or dopaminergic antidepressants, can cause serotonin syndrome. Bupropion also inhibits CYP2D6 and may further complicate toxicity.
How serious is the interaction between Bupropion and Methylthioninium chloride?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if methylene blue is urgently needed, withhold bupropion and monitor for serotonin syndrome for several days.
What other medicines interact with Methylthioninium chloride?
MediHelp also lists interactions of Methylthioninium chloride with, for example, Levomilnacipran, Linezolid, Buspirone. The full list is on the Methylthioninium chloride page.
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