Drug interactions
Bupropion + Mipomersen
Severity: Minor
Bupropion and Mipomersen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen can cause hepatotoxicity with raised transaminases and hepatic steatosis. Bupropion is rarely associated with liver enzyme elevations, so concurrent use may add modestly to hepatic monitoring concerns.
What this interaction means in plain words
Bupropion and Mipomersen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive hepatotoxic potential; no established pharmacokinetic interaction.
What to do
Monitor liver enzymes according to mipomersen labeling and investigate any elevation for contributing drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Mipomersen?
MediHelp rates the interaction as minor. Bupropion and Mipomersen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mipomersen can cause hepatotoxicity with raised transaminases and hepatic steatosis. Bupropion is rarely associated with liver enzyme elevations, so concurrent use may add modestly to hepatic monitoring concerns.
How serious is the interaction between Bupropion and Mipomersen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes according to mipomersen labeling and investigate any elevation for contributing drugs.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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