Drug interactions
Bupropion + Nicotine inhaled
Severity: Moderate
Bupropion and Nicotine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining bupropion with nicotine replacement can increase blood pressure. This combination is used for smoking cessation but requires blood pressure checks.
What this interaction means in plain words
Bupropion and Nicotine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pressor effects from noradrenergic activity of bupropion and sympathomimetic effects of nicotine.
What to do
Monitor blood pressure weekly at least during the early phase of combination therapy. Reduce or stop one agent if hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Nicotine inhaled?
MediHelp rates the interaction as moderate. Bupropion and Nicotine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining bupropion with nicotine replacement can increase blood pressure. This combination is used for smoking cessation but requires blood pressure checks.
How serious is the interaction between Bupropion and Nicotine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure weekly at least during the early phase of combination therapy. Reduce or stop one agent if hypertension develops.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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