Drug interactions
Bupropion + Nirmatrelvir
Severity: Minor
Bupropion and Nirmatrelvir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nirmatrelvir alone is not a known strong CYP2B6 inhibitor, and a clinically important change in bupropion exposure is not established. Effects, if any, would be modest.
What this interaction means in plain words
Bupropion and Nirmatrelvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion belongs to Central Nervous System; Nirmatrelvir belongs to Anti Virals.
Why it happens
Possible minor effect on CYP2B6-mediated bupropion metabolism; not well established.
What to do
No dose adjustment is needed; monitor for changes in bupropion response during the short course.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Other interactions of Nirmatrelvir
- Alfuzosin + Nirmatrelvir Contraindicated
- Amiodarone + Nirmatrelvir Contraindicated
- Apalutamide + Nirmatrelvir Contraindicated
- Carbamazepine + Nirmatrelvir Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
- Dronedarone + Nirmatrelvir Contraindicated
Frequently asked questions
Can I take Bupropion with Nirmatrelvir?
MediHelp rates the interaction as minor. Bupropion and Nirmatrelvir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nirmatrelvir alone is not a known strong CYP2B6 inhibitor, and a clinically important change in bupropion exposure is not established. Effects, if any, would be modest.
How serious is the interaction between Bupropion and Nirmatrelvir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for changes in bupropion response during the short course.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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