Drug interactions
Bupropion + Olanzapine / samidorphan
Severity: Moderate
Bupropion and Olanzapine / samidorphan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause sedation and orthostatic hypotension, and antipsychotics and bupropion both lower the seizure threshold. Bupropion's CYP2D6 inhibition has limited impact on olanzapine, which is mainly cleared via CYP1A2 and glucuronidation.
What this interaction means in plain words
Bupropion and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS and seizure-threshold lowering effects.
What to do
Monitor for orthostatic hypotension, sedation and seizures, particularly in patients with seizure risk factors. Titrate doses gradually.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Olanzapine / samidorphan?
MediHelp rates the interaction as moderate. Bupropion and Olanzapine / samidorphan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause sedation and orthostatic hypotension, and antipsychotics and bupropion both lower the seizure threshold. Bupropion's CYP2D6 inhibition has limited impact on olanzapine, which is mainly cleared via CYP1A2 and glucuronidation.
How serious is the interaction between Bupropion and Olanzapine / samidorphan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for orthostatic hypotension, sedation and seizures, particularly in patients with seizure risk factors. Titrate doses gradually.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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