Drug interactions
Bupropion + Promazine
Severity: Moderate
Bupropion and Promazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion inhibits CYP2D6 and may raise promazine concentrations, increasing sedation, hypotension and QT effects. Both drugs also lower seizure threshold, adding to seizure risk.
What this interaction means in plain words
Bupropion and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP2D6 inhibition by bupropion and additive lowering of seizure threshold.
What to do
Use the lowest effective doses of both drugs and monitor for sedation, orthostasis, ECG changes and seizures. Reduce the promazine dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Promazine?
MediHelp rates the interaction as moderate. Bupropion and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion inhibits CYP2D6 and may raise promazine concentrations, increasing sedation, hypotension and QT effects. Both drugs also lower seizure threshold, adding to seizure risk.
How serious is the interaction between Bupropion and Promazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses of both drugs and monitor for sedation, orthostasis, ECG changes and seizures. Reduce the promazine dose if adverse effects emerge.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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