Drug interactions
Bupropion + Sufentanil sl
Severity: Minor
Bupropion and Sufentanil sl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids such as sufentanil have weak serotonergic activity and have been linked to serotonin syndrome with other serotonergic drugs. Bupropion is not a classic serotonergic agent, so the risk is low. Bupropion can also lower the seizure threshold, and some opioids add to this risk.
What this interaction means in plain words
Bupropion and Sufentanil sl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive serotonergic effect; the interaction is not firmly established for bupropion.
What to do
No routine change is needed. Watch for agitation, tremor, hyperthermia or clonus, especially when starting or increasing doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Sufentanil sl?
MediHelp rates the interaction as minor. Bupropion and Sufentanil sl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids such as sufentanil have weak serotonergic activity and have been linked to serotonin syndrome with other serotonergic drugs. Bupropion is not a classic serotonergic agent, so the risk is low. Bupropion can also lower the seizure threshold, and some opioids add to this risk.
How serious is the interaction between Bupropion and Sufentanil sl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Watch for agitation, tremor, hyperthermia or clonus, especially when starting or increasing doses.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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