Drug interactions
Bupropion + Temocillin
Severity: Moderate
Bupropion and Temocillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion lowers the seizure threshold in a dose-related manner. Beta-lactam antibiotics can also be proconvulsant, particularly in renal impairment, so seizure risk may be additive. A pharmacokinetic interaction is not established.
What this interaction means in plain words
Bupropion and Temocillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive lowering of the seizure threshold; no established pharmacokinetic mechanism.
What to do
Use the lowest effective bupropion dose and adjust temocillin for renal function. Monitor for neurological signs and avoid the combination in patients with a seizure history.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Temocillin?
MediHelp rates the interaction as moderate. Bupropion and Temocillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion lowers the seizure threshold in a dose-related manner. Beta-lactam antibiotics can also be proconvulsant, particularly in renal impairment, so seizure risk may be additive. A pharmacokinetic interaction is not established.
How serious is the interaction between Bupropion and Temocillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective bupropion dose and adjust temocillin for renal function. Monitor for neurological signs and avoid the combination in patients with a seizure history.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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