Drug interactions
Bupropion + Ticarcillin
Severity: Moderate
Bupropion and Ticarcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion lowers the seizure threshold in a dose-related manner. High-dose ticarcillin, especially with renal impairment, can cause neurotoxicity and seizures, so the risks may add together.
What this interaction means in plain words
Bupropion and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive lowering of the seizure threshold; no established pharmacokinetic mechanism.
What to do
Keep the bupropion dose as low as effective and adjust ticarcillin for renal function. Monitor for neurological toxicity and avoid the combination in patients with a seizure history.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Ticarcillin?
MediHelp rates the interaction as moderate. Bupropion and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion lowers the seizure threshold in a dose-related manner. High-dose ticarcillin, especially with renal impairment, can cause neurotoxicity and seizures, so the risks may add together.
How serious is the interaction between Bupropion and Ticarcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Keep the bupropion dose as low as effective and adjust ticarcillin for renal function. Monitor for neurological toxicity and avoid the combination in patients with a seizure history.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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