Drug interactions
Bupropion + Trifluoperazine
Severity: Moderate
Bupropion and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion strongly inhibits CYP2D6, which contributes to trifluoperazine clearance, so phenothiazine levels may rise. Both drugs also lower the seizure threshold, so the combination adds to seizure risk. Extrapyramidal effects and sedation may increase.
What this interaction means in plain words
Bupropion and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bupropion inhibits CYP2D6 and both drugs lower the seizure threshold.
What to do
Monitor for extrapyramidal symptoms, sedation and QT effects, and consider a lower trifluoperazine dose. Use the lowest effective bupropion dose and avoid the combination in patients with a seizure history.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Trifluoperazine?
MediHelp rates the interaction as moderate. Bupropion and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion strongly inhibits CYP2D6, which contributes to trifluoperazine clearance, so phenothiazine levels may rise. Both drugs also lower the seizure threshold, so the combination adds to seizure risk. Extrapyramidal effects and sedation may increase.
How serious is the interaction between Bupropion and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and QT effects, and consider a lower trifluoperazine dose. Use the lowest effective bupropion dose and avoid the combination in patients with a seizure history.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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