Drug interactions
Bupropion + Tropisetron
Severity: Minor
Bupropion and Tropisetron: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tropisetron is metabolized largely by CYP2D6, so bupropion may raise its concentrations. The clinical impact is usually small, though adverse effects such as headache or dizziness may increase.
What this interaction means in plain words
Bupropion and Tropisetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Bupropion inhibits CYP2D6, reducing tropisetron clearance.
What to do
No routine dose change is needed; monitor for tropisetron adverse effects such as headache, dizziness and QT changes in at-risk patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion
- Bupropion + Isocarboxazid Contraindicated
- Bupropion + Linezolid Contraindicated
- Bupropion + Phenelzine Contraindicated
- Bupropion + Rasagiline Contraindicated
- Bupropion + Selegiline Contraindicated
- Bupropion + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Bupropion with Tropisetron?
MediHelp rates the interaction as minor. Bupropion and Tropisetron have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tropisetron is metabolized largely by CYP2D6, so bupropion may raise its concentrations. The clinical impact is usually small, though adverse effects such as headache or dizziness may increase.
How serious is the interaction between Bupropion and Tropisetron?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for tropisetron adverse effects such as headache, dizziness and QT changes in at-risk patients.
What other medicines interact with Bupropion?
MediHelp also lists interactions of Bupropion with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Bupropion page.
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