Drug interactions
Bupropion-naltrexone + Butalbital
Severity: Moderate
Bupropion-naltrexone and Butalbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Butalbital, a barbiturate, may induce enzymes that metabolize bupropion and reduce its levels and effect. Additive CNS depression is also possible.
What this interaction means in plain words
Bupropion-naltrexone and Butalbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated enzyme induction (CYP2B6) increases bupropion clearance.
What to do
Monitor for reduced bupropion response and sedation. Adjust the bupropion dose within labeled limits if efficacy falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Butalbital?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Butalbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Butalbital, a barbiturate, may induce enzymes that metabolize bupropion and reduce its levels and effect. Additive CNS depression is also possible.
How serious is the interaction between Bupropion-naltrexone and Butalbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced bupropion response and sedation. Adjust the bupropion dose within labeled limits if efficacy falls.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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