Drug interactions
Bupropion-naltrexone + Cannabidiol
Severity: Moderate
Bupropion-naltrexone and Cannabidiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabidiol can both inhibit and induce CYP2B6, the enzyme that converts bupropion to hydroxybupropion. Bupropion exposure may therefore change unpredictably, altering efficacy or adverse effects.
What this interaction means in plain words
Bupropion-naltrexone and Cannabidiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Cannabidiol belongs to Central Nervous System.
Why it happens
Cannabidiol modulates CYP2B6 activity, altering bupropion metabolism.
What to do
Monitor clinical response and tolerability, especially for seizure risk, and adjust the bupropion dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Cannabidiol
- Cannabidiol + Phenytoin Major
- Cannabidiol + Tacrolimus Major
- Cannabidiol + Valproic acid Major
- Abiraterone + Cannabidiol Moderate
- Alogliptin-pioglitazone + Cannabidiol Moderate
- Amiodarone + Cannabidiol Moderate
Frequently asked questions
Can I take Bupropion-naltrexone with Cannabidiol?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Cannabidiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabidiol can both inhibit and induce CYP2B6, the enzyme that converts bupropion to hydroxybupropion. Bupropion exposure may therefore change unpredictably, altering efficacy or adverse effects.
How serious is the interaction between Bupropion-naltrexone and Cannabidiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and tolerability, especially for seizure risk, and adjust the bupropion dose accordingly.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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