Drug interactions
Bupropion-naltrexone + Cefamandole
Severity: Minor
Bupropion-naltrexone and Cefamandole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cephalosporins, particularly at high doses or with renal impairment, have been associated with seizures. Together with bupropion, which lowers the seizure threshold, the risk may be somewhat increased.
What this interaction means in plain words
Bupropion-naltrexone and Cefamandole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive lowering of the seizure threshold; not firmly established.
What to do
Adjust the cefamandole dose for renal function and watch for neurotoxicity. Use the lowest effective bupropion dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Cefamandole?
MediHelp rates the interaction as minor. Bupropion-naltrexone and Cefamandole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cephalosporins, particularly at high doses or with renal impairment, have been associated with seizures. Together with bupropion, which lowers the seizure threshold, the risk may be somewhat increased.
How serious is the interaction between Bupropion-naltrexone and Cefamandole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Adjust the cefamandole dose for renal function and watch for neurotoxicity. Use the lowest effective bupropion dose.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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