Drug interactions
Bupropion-naltrexone + Cenobamate
Severity: Moderate
Bupropion-naltrexone and Cenobamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cenobamate induces CYP2B6 and may reduce bupropion exposure, causing loss of efficacy. Both drugs also affect seizure threshold and CNS function.
What this interaction means in plain words
Bupropion-naltrexone and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Cenobamate belongs to Central Nervous System.
Why it happens
Cenobamate induces CYP2B6, increasing bupropion metabolism.
What to do
Monitor therapeutic response and increase the bupropion dose within labeled limits if needed. Watch for sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Cenobamate
Frequently asked questions
Can I take Bupropion-naltrexone with Cenobamate?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Cenobamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cenobamate induces CYP2B6 and may reduce bupropion exposure, causing loss of efficacy. Both drugs also affect seizure threshold and CNS function.
How serious is the interaction between Bupropion-naltrexone and Cenobamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor therapeutic response and increase the bupropion dose within labeled limits if needed. Watch for sedation.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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