Drug interactions
Bupropion-naltrexone + Citalopram
Severity: Moderate
Bupropion-naltrexone and Citalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion may modestly raise citalopram levels and both drugs can lower seizure threshold. Citalopram's QT effect makes higher exposure undesirable.
What this interaction means in plain words
Bupropion-naltrexone and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Citalopram belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by bupropion may reduce citalopram clearance, with additive pharmacodynamic seizure-threshold lowering.
What to do
Use the lowest effective citalopram dose, monitor for adverse effects and QT risk factors, and avoid in patients with seizure risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Citalopram?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion may modestly raise citalopram levels and both drugs can lower seizure threshold. Citalopram's QT effect makes higher exposure undesirable.
How serious is the interaction between Bupropion-naltrexone and Citalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective citalopram dose, monitor for adverse effects and QT risk factors, and avoid in patients with seizure risk.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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