Drug interactions
Bupropion-naltrexone + Cyclosporine
Severity: Moderate
Bupropion-naltrexone and Cyclosporine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may alter bupropion exposure and both drugs can lower the seizure threshold. The clinical significance is uncertain but seizures are a concern.
What this interaction means in plain words
Bupropion-naltrexone and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Mechanism not firmly established; possible pharmacokinetic effect plus additive neurotoxic and seizure-threshold effects.
What to do
Use the lowest effective bupropion dose and monitor for neurological symptoms. Monitor cyclosporine levels.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Cyclosporine?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Cyclosporine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may alter bupropion exposure and both drugs can lower the seizure threshold. The clinical significance is uncertain but seizures are a concern.
How serious is the interaction between Bupropion-naltrexone and Cyclosporine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective bupropion dose and monitor for neurological symptoms. Monitor cyclosporine levels.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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