Drug interactions
Bupropion-naltrexone + Dexfenfluramine
Severity: Minor
Bupropion-naltrexone and Dexfenfluramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion strongly inhibits CYP2D6, which may raise dexfenfluramine concentrations. Dexfenfluramine has been withdrawn from the market, so this interaction has little current relevance.
What this interaction means in plain words
Bupropion-naltrexone and Dexfenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP2D6 inhibition by bupropion reduces dexfenfluramine metabolism.
What to do
Monitor for increased serotonergic or adverse effects if the combination is encountered.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Dexfenfluramine?
MediHelp rates the interaction as minor. Bupropion-naltrexone and Dexfenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bupropion strongly inhibits CYP2D6, which may raise dexfenfluramine concentrations. Dexfenfluramine has been withdrawn from the market, so this interaction has little current relevance.
How serious is the interaction between Bupropion-naltrexone and Dexfenfluramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased serotonergic or adverse effects if the combination is encountered.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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