Drug interactions
Bupropion-naltrexone + Dextroamphetamine transdermal
Severity: Moderate
Bupropion-naltrexone and Dextroamphetamine transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion inhibits CYP2D6, which contributes to amphetamine metabolism, and may increase amphetamine exposure. Higher levels raise the risk of serotonin syndrome, hypertension and tachycardia, and both drugs lower the seizure threshold.
What this interaction means in plain words
Bupropion-naltrexone and Dextroamphetamine transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP2D6 inhibition by bupropion reduces amphetamine clearance, with additive pharmacodynamic effects.
What to do
Start with a low amphetamine dose and titrate slowly. Monitor for serotonin syndrome, blood pressure and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Dextroamphetamine transdermal?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Dextroamphetamine transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion inhibits CYP2D6, which contributes to amphetamine metabolism, and may increase amphetamine exposure. Higher levels raise the risk of serotonin syndrome, hypertension and tachycardia, and both drugs lower the seizure threshold.
How serious is the interaction between Bupropion-naltrexone and Dextroamphetamine transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low amphetamine dose and titrate slowly. Monitor for serotonin syndrome, blood pressure and heart rate.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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