Drug interactions
Bupropion-naltrexone + Dextroamphetamine
Severity: Moderate
Bupropion-naltrexone and Dextroamphetamine: moderate interaction.
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For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion may raise dextroamphetamine exposure and both stimulate the CNS and lower seizure threshold, raising risk of agitation, hypertension and seizures.
What this interaction means in plain words
Bupropion-naltrexone and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Dextroamphetamine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by bupropion reduces amphetamine metabolism, with additive pharmacodynamic CNS stimulation.
What to do
Use the lowest effective doses and monitor blood pressure, heart rate and neuropsychiatric symptoms; avoid in patients with seizure history.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Dextroamphetamine?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Dextroamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion may raise dextroamphetamine exposure and both stimulate the CNS and lower seizure threshold, raising risk of agitation, hypertension and seizures.
How serious is the interaction between Bupropion-naltrexone and Dextroamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor blood pressure, heart rate and neuropsychiatric symptoms; avoid in patients with seizure history.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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