Drug interactions
Bupropion-naltrexone + Diazepam intranasal
Severity: Moderate
Bupropion-naltrexone and Diazepam intranasal: moderate interaction.
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For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diazepam causes CNS depression, and the combination with bupropion may produce additive psychomotor impairment. Benzodiazepine withdrawal and bupropion both also influence seizure risk.
What this interaction means in plain words
Bupropion-naltrexone and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic CNS effects; abrupt benzodiazepine discontinuation can lower seizure threshold alongside bupropion.
What to do
Counsel patients about drowsiness and driving. Avoid abrupt benzodiazepine discontinuation and monitor for seizures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Diazepam intranasal?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Diazepam intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Diazepam causes CNS depression, and the combination with bupropion may produce additive psychomotor impairment. Benzodiazepine withdrawal and bupropion both also influence seizure risk.
How serious is the interaction between Bupropion-naltrexone and Diazepam intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and driving. Avoid abrupt benzodiazepine discontinuation and monitor for seizures.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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