Drug interactions
Bupropion-naltrexone + Donepezil
Severity: Minor
Bupropion-naltrexone and Donepezil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion inhibits CYP2D6, one of the enzymes that metabolize donepezil, and may modestly raise donepezil concentrations. This may increase cholinergic effects such as nausea, bradycardia or vomiting.
What this interaction means in plain words
Bupropion-naltrexone and Donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bupropion-naltrexone belongs to Miscellaneous; Donepezil belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated donepezil metabolism by bupropion.
What to do
Monitor for cholinergic adverse effects including gastrointestinal upset and bradycardia; adjust donepezil dose if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Bupropion-naltrexone and Donepezil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Bupropion-naltrexone with Donepezil?
MediHelp rates the interaction as minor. Bupropion-naltrexone and Donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bupropion inhibits CYP2D6, one of the enzymes that metabolize donepezil, and may modestly raise donepezil concentrations. This may increase cholinergic effects such as nausea, bradycardia or vomiting.
How serious is the interaction between Bupropion-naltrexone and Donepezil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cholinergic adverse effects including gastrointestinal upset and bradycardia; adjust donepezil dose if needed.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
