Drug interactions
Bupropion-naltrexone + Ethanol
Severity: Moderate
Bupropion-naltrexone and Ethanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Alcohol use with bupropion has been associated with reduced alcohol tolerance and neuropsychiatric events. Heavy drinking or abrupt alcohol withdrawal also raises the risk of seizures during bupropion treatment.
What this interaction means in plain words
Bupropion-naltrexone and Ethanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS effects and lowered seizure threshold, including during alcohol withdrawal.
What to do
Advise minimizing or avoiding alcohol during treatment. Do not start in patients undergoing abrupt alcohol withdrawal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Ethanol?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Ethanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Alcohol use with bupropion has been associated with reduced alcohol tolerance and neuropsychiatric events. Heavy drinking or abrupt alcohol withdrawal also raises the risk of seizures during bupropion treatment.
How serious is the interaction between Bupropion-naltrexone and Ethanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise minimizing or avoiding alcohol during treatment. Do not start in patients undergoing abrupt alcohol withdrawal.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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