Drug interactions
Bupropion-naltrexone + Gabapentin
Severity: Moderate
Bupropion-naltrexone and Gabapentin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gabapentin causes sedation and, especially with other CNS depressants, respiratory depression. Both gabapentin and bupropion can also affect seizure control, and the combination may cause additive CNS effects such as dizziness and impaired cognition.
What this interaction means in plain words
Bupropion-naltrexone and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bupropion-naltrexone belongs to Miscellaneous; Gabapentin belongs to Central Nervous System.
Why it happens
Additive central nervous system effects; gabapentin is a CNS depressant while bupropion lowers seizure threshold and may alter alertness.
What to do
Use the lowest effective doses and monitor for sedation, dizziness and respiratory depression, particularly in elderly or respiratory-compromised patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Gabapentin
Frequently asked questions
Can I take Bupropion-naltrexone with Gabapentin?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Gabapentin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gabapentin causes sedation and, especially with other CNS depressants, respiratory depression. Both gabapentin and bupropion can also affect seizure control, and the combination may cause additive CNS effects such as dizziness and impaired cognition.
How serious is the interaction between Bupropion-naltrexone and Gabapentin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation, dizziness and respiratory depression, particularly in elderly or respiratory-compromised patients.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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