Drug interactions
Bupropion-naltrexone + Iobenguane i
Severity: Major
Bupropion-naltrexone and Iobenguane i: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iobenguane enters neuroendocrine cells via the norepinephrine transporter. Bupropion inhibits catecholamine reuptake and may compete with iobenguane uptake, which could reduce tumor delivery and therapeutic or imaging efficacy.
What this interaction means in plain words
Bupropion-naltrexone and Iobenguane i can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of norepinephrine transporter-mediated uptake by bupropion reduces cellular uptake of iobenguane.
What to do
Withhold bupropion-naltrexone for at least 5 half-lives before iobenguane dosimetry or therapeutic doses, and do not restart until at least 7 days after each dose, per labeling for interfering drugs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Iobenguane i?
MediHelp rates the interaction as major. Bupropion-naltrexone and Iobenguane i can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Iobenguane enters neuroendocrine cells via the norepinephrine transporter. Bupropion inhibits catecholamine reuptake and may compete with iobenguane uptake, which could reduce tumor delivery and therapeutic or imaging efficacy.
How serious is the interaction between Bupropion-naltrexone and Iobenguane i?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Withhold bupropion-naltrexone for at least 5 half-lives before iobenguane dosimetry or therapeutic doses, and do not restart until at least 7 days after each dose, per labeling for interfering drugs.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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