Drug interactions
Bupropion-naltrexone + Ioflupane i
Severity: Moderate
Bupropion-naltrexone and Ioflupane i: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion binds the dopamine transporter and may reduce ioflupane I-123 uptake, potentially interfering with DaTscan interpretation. This could cause a false-positive or equivocal image.
What this interaction means in plain words
Bupropion-naltrexone and Ioflupane i can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competitive binding at the dopamine transporter reduces radioligand uptake.
What to do
Consider withholding bupropion for an adequate washout period before imaging when clinically feasible, and interpret scans with awareness of this effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Ioflupane i?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Ioflupane i can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion binds the dopamine transporter and may reduce ioflupane I-123 uptake, potentially interfering with DaTscan interpretation. This could cause a false-positive or equivocal image.
How serious is the interaction between Bupropion-naltrexone and Ioflupane i?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider withholding bupropion for an adequate washout period before imaging when clinically feasible, and interpret scans with awareness of this effect.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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