Drug interactions
Bupropion-naltrexone + Lofepramine
Severity: Major
Bupropion-naltrexone and Lofepramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion inhibits CYP2D6 and may raise levels of lofepramine and its active metabolite desipramine. Both drugs lower the seizure threshold, increasing seizure risk and tricyclic toxicity.
What this interaction means in plain words
Bupropion-naltrexone and Lofepramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP2D6 inhibition by bupropion plus additive lowering of seizure threshold.
What to do
Avoid if possible; otherwise use low doses with slow titration. Monitor for seizures and cardiac or anticholinergic toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Lofepramine?
MediHelp rates the interaction as major. Bupropion-naltrexone and Lofepramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Bupropion inhibits CYP2D6 and may raise levels of lofepramine and its active metabolite desipramine. Both drugs lower the seizure threshold, increasing seizure risk and tricyclic toxicity.
How serious is the interaction between Bupropion-naltrexone and Lofepramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise use low doses with slow titration. Monitor for seizures and cardiac or anticholinergic toxicity.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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