Drug interactions
Bupropion-naltrexone + Lorcaserin
Severity: Moderate
Bupropion-naltrexone and Lorcaserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorcaserin is a serotonin 5-HT2C agonist, and combining it with a serotonergic or dopaminergic-noradrenergic agent like bupropion could theoretically contribute to serotonin syndrome. Both are anti-obesity agents and are not intended to be used together. Lorcaserin has also been withdrawn from the US market.
What this interaction means in plain words
Bupropion-naltrexone and Lorcaserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effects; the interaction is largely theoretical and clinical evidence is limited.
What to do
Avoid concurrent use of two weight-loss agents. If used, monitor for agitation, tremor, hyperreflexia, diarrhea and hyperthermia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Lorcaserin?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Lorcaserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorcaserin is a serotonin 5-HT2C agonist, and combining it with a serotonergic or dopaminergic-noradrenergic agent like bupropion could theoretically contribute to serotonin syndrome. Both are anti-obesity agents and are not intended to be used together. Lorcaserin has also been withdrawn from the US market.
How serious is the interaction between Bupropion-naltrexone and Lorcaserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two weight-loss agents. If used, monitor for agitation, tremor, hyperreflexia, diarrhea and hyperthermia.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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