Drug interactions
Bupropion-naltrexone + Nefazodone
Severity: Moderate
Bupropion-naltrexone and Nefazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nefazodone inhibits CYP3A4 and may alter bupropion metabolism, and it also has serotonergic activity. Bupropion has dose-related seizure risk and its exposure and that of its metabolites could rise, though the interaction is not well characterized.
What this interaction means in plain words
Bupropion-naltrexone and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nefazodone and its metabolites may alter bupropion disposition, with additive CNS effects; the exact mechanism is not firmly established.
What to do
Avoid if possible, since there are safer antidepressant choices. If used together, keep the bupropion dose as low as feasible and monitor for seizures, agitation and neuropsychiatric effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Nefazodone?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Nefazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nefazodone inhibits CYP3A4 and may alter bupropion metabolism, and it also has serotonergic activity. Bupropion has dose-related seizure risk and its exposure and that of its metabolites could rise, though the interaction is not well characterized.
How serious is the interaction between Bupropion-naltrexone and Nefazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, since there are safer antidepressant choices. If used together, keep the bupropion dose as low as feasible and monitor for seizures, agitation and neuropsychiatric effects.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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