Drug interactions
Bupropion-naltrexone + Promazine
Severity: Moderate
Bupropion-naltrexone and Promazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bupropion strongly inhibits CYP2D6, which can raise promazine exposure and increase sedation, hypotension and QT-related risk. Both bupropion and phenothiazines can lower the seizure threshold, so the combination may raise seizure risk.
What this interaction means in plain words
Bupropion-naltrexone and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Bupropion and its metabolites inhibit CYP2D6, reducing promazine metabolism, and both drugs additively lower seizure threshold.
What to do
Use the lowest effective bupropion dose and monitor for seizures, sedation, hypotension and ECG changes. Consider reducing the promazine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Frequently asked questions
Can I take Bupropion-naltrexone with Promazine?
MediHelp rates the interaction as moderate. Bupropion-naltrexone and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bupropion strongly inhibits CYP2D6, which can raise promazine exposure and increase sedation, hypotension and QT-related risk. Both bupropion and phenothiazines can lower the seizure threshold, so the combination may raise seizure risk.
How serious is the interaction between Bupropion-naltrexone and Promazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective bupropion dose and monitor for seizures, sedation, hypotension and ECG changes. Consider reducing the promazine dose if adverse effects appear.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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